Professor, Department of Materials Science, University of Tsukuba
Concurrent Professor, Department of Medical Science, University of Tsukuba
Center for Research in Isotopes and Environmental Dynamics (CRiED), University of Tsukuba
Yukio Nagasaki graduated University of Tokyo in 1982 and received Ph.D. in Department of Industrial Chemistry, Faculty of Engineering, University of Tokyo in 1987. Since 1987, he became Research associate in Department of Industrial Chemistry, Research associate, Assistant Professor and Professor in Department of Materials Science, Science University of Tokyo. He moved to University of Tsukuba in 2004 as a professor.
His research interest is directed to the creation of new functional materials by a novel polymerization technique. End-functionalized poly(ethylene glycol) (PEG) as surface modifier and novel nanoparticles as intelligent drug vehicle are his main targets for novel material design. He is also interested in creating high performance biointerfaces, including non-fouling and certain bio-recognition characters. They have found that the PEG bonded chain surface with a mixture of long and short chains almost completely reduces nonspecific protein adsorption (Uchida et al., Ana. Chem., 77, 1075, 2005). The antibody/PEG co-immobilized surface increased the PEG linked chain density and surface antibody reactivity (Nagasaki et al., J. Coll. Int. Sci., 307, 524, 2007). This immunochemical enhancement effect is expected to be three phenomena that create a highly functional surface of highly versatile biomaterial.
Recently, Nitroxide Radical Containing Nanoparticles (RNP) with the ability of scavenging ROS to reduce oxidative stress activity was developed (Yoshitomi et al., Bioconjugate Chemistry, 20, 2792 (2009)). Using RNP, ROS damage due to cerebral ischemia reperfusion is effectively reduced (Marushima et al., Neurosurgery, 2011). RNP is also effective not only for the Alzheimer’s disease, but also for cancer, and ulcerative colitis. Antiinflammation by nanoparticles is very promising.
In the process of these research on biofunctional materials at Science University of Tokyo and University of Tsukuba, he made surface modification of protein modification polymers and diagnostic particles, which were commercialized from Nippon Oil&Fat and JSR, respectively. In addition, a high efficient cell culture dish was commercialized from Toyogosei Industry Co., Ltd. As described above, antioxidative nanoparticle is now developing and start to collaborate with several companies. He wishes to commercialize them near future.