27 C
Ho Chi Minh City
July 13, 2020 21:38 (GMT+0700 +07:00)

ABSTRACT

Current and future applications of molecular biology in management of cancer with references to current World Health Organization of Classification of tumours Lam, Alfred K The use of molecular biology is now part of the routine clinical practice in the management of cancers as well as in oncology researches.  For instance, 54 different biomarkers are mentioned 98 times across the...
The structure, function and biomechanical properties of soft-biological tissues (heart, arteries, bladder, tendon, skin etc) are intimately related to their mechanical environment. Understanding this ‘mechanobiological’ relationship provides mechanistic insight into tissue function and dysfunction during development, aging and disease . In this talk, I will overview in silico modelling approaches for simulating the biomechanics and evolving mechanobiology of several soft-tissue...
Myocardial infarction is a major cause of mortality and morbidity. Typically, the underlying disease is atherosclerosis. Over time patients develop atherosclerotic plaques that become unstable and ultimately some of these vulnerable plaques rupture and cause a thrombotic occlusion of the coronary arteries and thereby cause a myocardial infarction. Many patients die right away with their first myocardial infarction and...
Electrochemical analysis is a promising method for biosensing. In our current work, a highly sensitive nanostructured electrochemical biosensor based on a 3D sensing element featuring uniformly deposited gold nanoparticles has been developed. A modified anodic aluminum oxide (AAO) barrier-layer surface is used as the template for nickel thin film deposition. After etching the AAO template off, a 3D mold...
Biomedical Engineering Study of Diseases of the Eye: Previous Successes and New Opportunities Bioengineering methods have elucidated the details of a variety of ocular diseases processes including the role of mechanics in the elevated pressure characteristic of glaucoma and in the resulting damage to the optic nerve, the role of lipid accumulation in age-related macular degeneration, and the role of...
Macromolecular Self-assembly: From Polyethylene to Dendrimer-based Cell-like Mimics The talk will outline research carried out over the past decade with computer simulation techniques aimed at probing macromolecular self-assembly. Recent results on polyethylene crystallization will give an indication of what is possible with state-of-the-art computers. The talk will also review novel synthetic work carried out over the past decade on advanced...
A parameterised mathematical model to elucidate osteoblast cell growth in a phosphate-glass microcarrier culture Tissue engineering has the potential to augment bone grafting. Employing microcarriers as cell-expansion vehicles is a promising bottom-up bone tissue engineering strategy. Here we propose a collaborative approach between experimental work and mathematical modelling to develop protocols for growing microcarrier-based engineered constructs of clinically relevant size....
Design of molecular self-assembling drugs Reactive oxygen species (ROS) is known to play a variety of roles at many important event opportunities in vivo. However, overproduction of ROS causes serious adverse side effects in the body. Many drugs have been applied to reduce excessively produced ROS. However, low molecular weight (LMW) antioxidants spread nonspecifically to the whole body and are...
A novel chemo-mechano-biological model of arterial tissue growth and remodelling Arterial growth and remodelling (G&R) is mediated by vascular cells in response to their chemical and mechanical environment. To date, mechanical and biochemical stimuli tend to be modelled separately, however this ignores their complex interplay. Here, we present a novel mathematical model of arterial chemo-mechano-biology. We illustrate its application to...
Novel Approaches to Evaluate the Amyloid Cascade Hypothesis This talk will describe a multidisciplinary approach by the integration of medicinal chemistry with molecular imaging and drug delivery to re-assess the role of amyloid in Alzheimer’s disease (AD). Particularly, the investigation of the role of oxidative stress in the initiation of amyloid aggregation will be discussed. The brain is more vulnerable...